Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jun;16(6):667-9.
doi: 10.1038/nsmb.1604. Epub 2009 May 17.

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

Ivan Laponogov  1 , Maninder K Sohi, Dennis A Veselkov, Xiao-Su Pan, Ritica Sawhney, Andrew W Thompson, Katherine E McAuley, L Mark Fisher, Mark R Sanderson
Affiliations

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

Ivan Laponogov et al. Nat Struct Mol Biol. 2009 Jun.

Abstract

Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA transport through a double-stranded DNA break. We present the structures of cleavage complexes formed by the Streptococcus pneumoniae ParC breakage-reunion and ParE TOPRIM domains of topoisomerase IV stabilized by moxifloxacin and clinafloxacin, two antipneumococcal fluoroquinolones. These structures reveal two drug molecules intercalated at the highly bent DNA gate and help explain antibacterial quinolone action and resistance.

PubMed Disclaimer

References

    1. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92 - PubMed
    1. J Mol Graph. 1996 Feb;14(1):33-8, 27-8 - PubMed
    1. Curr Drug Targets. 2003 Feb;4(2):181-90 - PubMed
    1. Nature. 1981 Apr 30;290(5809):744-9 - PubMed
    1. Antimicrob Agents Chemother. 2008 Feb;52(2):385-92 - PubMed

Publication types

MeSH terms

LinkOut - more resources