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. 2009 Jun;41(6):645-7.
doi: 10.1038/ng.387. Epub 2009 May 17.

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk  1 , Guangju Zhai, Joyce B J van Meurs, Michael M P J Verbiest, Jenny A Visser, Karol Estrada, Fernando Rivadeneira, Frances M Williams, Lynn Cherkas, Panos Deloukas, Nicole Soranzo, Jules J de Keyzer, Victor J M Pop, Paul Lips, Corinne E I Lebrun, Yvonne T van der Schouw, Diederick E Grobbee, Jacqueline Witteman, Albert Hofman, Huibert A P Pols, Joop S E Laven, Tim D Spector, André G Uitterlinden
Affiliations

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Lisette Stolk et al. Nat Genet. 2009 Jun.

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

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Figure 1
Figure 1
Meta-analysis of risk for early menopause (<50 years) by genotype for the six genome-wide-significant hits. (a) rs7333181 on chromosome 13. (b) rs1551562 on chromosome 19. (c) rs1172822 on chromosome 19. (d) rs2384687 on chromosome 19. (e) rs897798 on chromosome 19. (f) rs236114 on chromosome 20.
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