C-H hydroxylation using a heterocyclic catalyst and aqueous H2O2

Abstract

Substituted benzoxathiazines function as catalysts for the selective hydroxylation of tertiary C-H bonds. Mechanistic studies have revealed an unanticipated disparity between oxaziridine reactivity and catalyst performance and have given way to a new catalyst and an aqueous H(2)O(2) reaction protocol that greatly facilitate such transformations (see scheme).