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. 2009 Aug;53(8):3579-81.
doi: 10.1128/AAC.00072-09. Epub 2009 May 18.

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii

Carole Moubareck  1 , Sylvie Brémont, Marie-Christine Conroy, Patrice Courvalin, Thierry Lambert
Affiliations

GES-11, a novel integron-associated GES variant in Acinetobacter baumannii

Carole Moubareck et al. Antimicrob Agents Chemother. 2009 Aug.

Abstract

New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.

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Figures

FIG. 1.
FIG. 1.
Schematic representation of integrons containing blaGES-like genes. Arrows represent coding sequences and indicate the direction of transcription. Rectangles represent attC sites. (A) blaGES-11 containing a class 1 integron of pIP847; (B) blaGES-1 containing a class 1 integron of pTK-1 (15); (C) blaGES-1 containing a class 3 integron of p22K9 (4); (D) blaGES-1 containing a class 1 integron of pC23 (6); (E) blaGES-2 containing a class 1 integron of p22K9 (GenBank accession no. AF326355); and (F) blaGES-3 containing a class 1 integron of pKGB525 (21).
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References

    1. Bergogne-Berezin, E., and K. J. Towner. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148-165. - PMC - PubMed
    1. Birnboim, H. C., and J. Doly. 1979. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 7:1513-1523. - PMC - PubMed
    1. Comité de l'Antibiogramme de la Société Française de Microbiologie. 2009. Communiqué 2009. Société Française de Microbiologie, Paris, France. http://www.sfm.asso.fr.
    1. Correia, M., F. Boavida, F. Grosso, M. J. Salgado, L. M. Lito, J. M. Cristino, S. Mendo, and A. Duarte. 2003. Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 47:2838-2843. - PMC - PubMed
    1. Depardieu, F., I. Podglajen, R. Leclercq, E. Collatz, and P. Courvalin. 2007. Modes and modulations of antibiotic resistance gene expression. Clin. Microbiol. Rev. 20:79-114. - PMC - PubMed

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