Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Aug;8(8):4144-50.
doi: 10.1021/pr900386f.

(1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations

Gonçalo Graça  1 , Iola F Duarte, António S Barros, Brian J Goodfellow, Sílvia Diaz, Isabel M Carreira, Ana Bela Couceiro, Eulália Galhano, Ana M Gil
Affiliations

(1)H NMR based metabonomics of human amniotic fluid for the metabolic characterization of fetus malformations

Gonçalo Graça et al. J Proteome Res. 2009 Aug.

Abstract

An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus gender and gestational and maternal ages) were shown not to induce detectable compositional trends in the control group considered. Malformed fetuses showed variations in glucose, some amino acids and organic acids and proteins. In tandem with enzymatic assays, these NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here.

PubMed Disclaimer

Publication types

LinkOut - more resources