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Review
. 2009 Jul;215(1):3-13.
doi: 10.1111/j.1469-7580.2008.01034.x. Epub 2009 Apr 22.

Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation

Harmeet Singh  1 , John D Aplin
Affiliations
Review

Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation

Harmeet Singh et al. J Anat. 2009 Jul.

Abstract

Cell adhesion in endometrial epithelium is regulated to maintain the continuity and protectiveness of the luminal covering cell layer while permitting interstitial implantation of the embryo during a restricted period of about 4 days. Many apparently normal embryos fail to implant, and epithelial-embryo adhesion remains a poorly understood phenomenon. After menstruation, epithelial regeneration occurs by epiboly from the basal residues of glands, an activity that requires migration on extracellular matrix as well as cell-cell cohesion. Here we review current knowledge of adhesion molecules in the epithelium.

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References

    1. Afify AM, Craig S, Paulino AF. Temporal variation in the distribution of hyaluronic acid, CD44s, and CD44v6 in the human endometrium across the menstrual cycle. Appl Immunohistochem Mol Morphol. 2006;14:328–333. - PubMed
    1. Albers A, Thie M, Hohn HP, Denker HW. Differential expression and localization of integrins and CD44 in the membrane domains of human uterine epithelial cells during the menstrual cycle. Acta Anat (Basel) 1995;153:12–19. - PubMed
    1. Aplin JD. Glycans as biochemical markers of human endometrial secretory differentation. J Reprod Fertil. 1991;91:525–541. - PubMed
    1. Aplin JD. Adhesion molecules in implantation. Rev Reprod. 1997;2:84–93. - PubMed
    1. Aplin JD. The cell biological basis of human implantation. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14:757–764. - PubMed

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