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Comparative Study
. 2009 Jun;36(6):468-73.
doi: 10.1111/j.1600-051X.2009.01410.x. Epub 2009 Apr 22.

Aggressive periodontitis is likely influenced by a few small effect genes

Flavia M de Carvalho  1 , Eduardo M B Tinoco, Manika Govil, Mary L Marazita, Alexandre R Vieira
Affiliations
Comparative Study

Aggressive periodontitis is likely influenced by a few small effect genes

Flavia M de Carvalho et al. J Clin Periodontol. 2009 Jun.

Abstract

Aim: To evaluate the inheritance mode of aggressive periodontitis in a collection of families with a similar geographic origin.

Materials and methods: Segregation analysis was performed in pedigree data from 74 families by the use of the SEGREG program of SAGE v.5.4.2. Homogeneous no transmission, homogeneous Mendelian transmission, homogeneous general transmission, semi-general transmission and heterogeneous general transmission models were tested assuming the prevalence of aggressive periodontitis as 1% and no deviations from Hardy-Weinberg equilibrium. The parameters of the model were estimated by the method of maximum likelihood, which provides the overall ln (likelihood), -2ln and the AIC (Akaike's score) for each model. The likelihood ratio test (LRT) was used to compare each model against a fully general model (p>0.05).

Results: The most parsimonious mode of inheritance was the semi-general transmission model that allows the heterozygote transmission probability to vary.

Conclusion: This result provides strong support for the hypothesis that genetic factors play a role in aggressive periodontitis and that a few loci, each with relatively small effects, contribute to aggressive periodontitis, with or without interaction with environmental factors.

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Conflict of interest statement

Conflict of interest and sources of funding statement

The authors declare that there are no conflicts in this study. This study was supported in part by a grant from the Brazilian government: CAPES.

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