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Comment
. 2009 May 8;5(5):420-1.
doi: 10.1016/j.chom.2009.05.004.

Influenza A virus TRIMs the type I interferon response

Stephan Ludwig, Thorsten Wolff
Free article
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Influenza A virus TRIMs the type I interferon response

Stephan Ludwig et al. Cell Host Microbe. .
Free article

Abstract

The virulence of many pathogenic viruses depends on suppression of the innate type I interferon defense. For influenza viruses, a unique strategy has now been unraveled, as the viral nonstructural protein 1 was shown to inhibit activation of the pathogen recognition receptor RIG-I by binding the ubiquitin ligase TRIM25.

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