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Randomized Controlled Trial
. 2009 Jun;18(6):795-801.
doi: 10.1089/jwh.2008.0988.

Association of oxidative stress, iron, and centralized fat mass in healthy postmenopausal women

Betsy L Crist  1 , D Lee Alekel, Laura M Ritland, Laura N Hanson, Ulrike Genschel, Manju B Reddy
Affiliations
Randomized Controlled Trial

Association of oxidative stress, iron, and centralized fat mass in healthy postmenopausal women

Betsy L Crist et al. J Womens Health (Larchmt). 2009 Jun.

Abstract

Objective: Centralized adiposity, insulin resistance, excess iron, and elevated oxidative stress place postmenopausal women at risk for atherosclerotic cardiovascular disease (CVD). The objective of this study was to determine the relationship among excess iron, oxidative stress, and centralized fat mass in healthy postmenopausal women.

Methods: The parent project recruited healthy women for a randomized, double-blind, clinical trial designed to examine the effect of soy isoflavones on bone. At baseline (n = 122), we measured three antioxidant enzymes, iron status indices (serum ferritin among others), oxidative stress indices (oxidized low-density lipoprotein [oxLDL], urinary isoprostanes [PGF(2alpha)], protein carbonyls, DNA damage), and waist, hip, and thigh fat mass using dual-energy x-ray absorptiometry (DXA). We calculated insulin resistance using the homeostasis model assessment (HOMA). Multiple regression analysis was used to determine the CVD risk factors that contributed to oxidative stress and centralized fat mass (waist + hip/thigh = AndGynFM ratio).

Results: Almost 14% (p < 0.0005) of the variability in oxLDL was accounted for by AndGynFM ratio (6.1%, p < 0.0005), age (4.0%, p = 0.012), and serum iron (2.8%, p = 0.053). Similarly, 16% (p < 0.0001) of the variability in PGF(2alpha) was accounted for by the AndGynFM ratio (4.8%, p = 0.011), HOMA (3.9%, p = 0.021), and serum iron (2.7%, p = 0.054). We accounted for 33% (p </= 0.0001) of the variability in AndGynFM ratio by high-density lipoprotein cholesterol (HDL-C) (4.3%, p = 0.008), ferritin (4.9%, p = 0.005), HOMA (4.5%, p = 0.006), oxLDL (2.6%, p = 0.04), and PGF(2alpha) (3.0%, p = 0.025).

Conclusions: Our study suggests that reducing centralized fat mass and maintaining a favorable lipid profile, antioxidant status, and iron status all may be important in protecting postmenopausal women from atherosclerotic CVD.

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Figures

FIG. 1.
FIG. 1.
Subject enrollment flow chart.
See this image and copyright information in PMC

References

    1. Institute of Medicine. National Academy of Sciences, Food and Nutrition Board, Panel on Dietary Antioxidants and Related Compounds 2000: Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000.
    1. Cracowski JL. Devillier P. Durand T. Stanke-Labesque F. Bessard G. Vascular biology of the isoprostanes. J Vasc Res. 2001;38:93–103. - PubMed
    1. Nordbo L. Bonaa KH. Nordoy A. Serum ferritin, sex hormones, and cardiovascular risk factors in healthy women. Arterioscler Thromb. 1994;14:857–861. - PubMed
    1. Masse PG. Dosy J. Cole DEC. Evroski J. Allard J. D'Astous M. Is serum ferritin an additional cardiovascular risk factor for all postmenopausal women? Ann Nutr Metab. 2004;48:381–389. - PubMed
    1. Corti MC. Gaziano M. Hennekens CH. Iron status and risk of cardiovascular disease. Ann Epidemiol. 1997;7:62–68. - PubMed

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