Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec;15(12):1146-53.
doi: 10.1111/j.1469-0691.2009.02746.x. Epub 2009 May 18.

Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007

L Ren  1 , R Gonzalez, Z Wang, Z Xiang, Y Wang, H Zhou, J Li, Y Xiao, Q Yang, J Zhang, L Chen, W Wang, Y Li, T Li, X Meng, Y Zhang, G Vernet, G Paranhos-Baccalà, J Chen, Q Jin, J Wang
Affiliations

Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007

L Ren et al. Clin Microbiol Infect. 2009 Dec.

Abstract

To determine the aetiological role and epidemiological profile of common respiratory viruses in adults with acute respiratory tract infections (ARTIs), a 2-year study was conducted in Beijing, China, from May 2005 to July 2007. Nose and throat swab samples from 5808 ARTI patients were analysed by PCR methods for common respiratory viruses, including influenza viruses (IFVs) A, B, and C, parainfluenza viruses (PIVs) 1-4, enteroviruses (EVs), human rhinoviruses (HRVs), respiratory syncytial virus (RSV), human metapneumovirus (HMPV), human coronaviruses (HCoVs) OC43, 229E, NL63, and HKU1, and adenoviruses (ADVs). Viral pathogens were detected in 34.6% of patient samples, and 1.6% of the patients tested positive for more than one virus. IFVs (19.3%) were the dominant agents detected, followed by HRVs (6.5%), PIVs (4.3%), EVs (3.2%), and HCoVs (1.1%). ADVs, RSV and HMPV were also detected (<1%). The viral detection rates differed significantly between infections of the lower and upper respiratory tracts in the sample population: PIVs, the second most commonly detected viral agents in lower acute respiratory tract infections (LRTIs), were more prevalent than in upper acute respiratory tract infections, indicating that the pathogenic role of PIVs in LRTIs should be investigated. Currently, this study is the largest-scale investigation of respiratory virus infections in China with multiple agent detection, providing baseline data for further studies of respiratory virus infections in adults with ARTIs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Numbers of patients tested and numbers with positive virus detection for each month of the investigation.
Figure 2
Figure 2
Numbers of patients with positive detection of individual viruses, and detection rate (% of patients) for each month of the investigation. (a) influenza viruses (IFVs); (b) human rhinovirus (HRV); (c) parainfluenza viruses (PIVs); (d) enteroviruses (EVs); (e) human coronaviruses (HCoVs).
See this image and copyright information in PMC

References

    1. Coiras MT, Pérez‐Breña P, García ML, Casas I. Simultaneous detection of influenza A, B, and C viruses, respiratory syncytial virus, and adenoviruses in clinical samples by multiplex reverse transcription nested‐PCR assay. J Med Virol 2003; 69: 132–144. - PubMed
    1. Druce J, Tran T, Kelly H et al. Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002–2003. J Med Virol 2005; 75: 122–129. - PMC - PubMed
    1. Pierangeli A, Gentile M, Di Marco P et al. Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, Italy. J Med Virol 2007; 79: 463–468. - PMC - PubMed
    1. Gröndahl B, Puppe W, Hoppe A, Kühne I, Weigl JA, Schmitt HJ. Rapid identification of nine microorganisms causing acute respiratory tract infections by single‐tube multiplex reverse transcription‐PCR: feasibility study. J Clin Microbiol 1999; 37: 1–7. - PMC - PubMed
    1. Fouchier RA, Rimmelzwaan GF, Kuiken T, Osterhaus AD. Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses. Curr Opin Infect Dis 2005; 18: 141–146. - PubMed

Publication types

MeSH terms