doi: 10.1016/j.bmc.2009.05.001.
Epub 2009 May 6.
Synthesis and in vitro anti-hepatitis B virus activity of 6H-[1]benzothiopyrano[4,3-b]quinolin-9-ols
Affiliations
- PMID: 19457674
- DOI: 10.1016/j.bmc.2009.05.001
Item in Clipboard
Synthesis and in vitro anti-hepatitis B virus activity of 6H-[1]benzothiopyrano[4,3-b]quinolin-9-ols
Bioorg Med Chem.
.
Abstract
A series of novel 6H-[1]benzothiopyrano[4,3-b]quinoline derivatives were prepared and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in human hepatoblastoma-derived liver Hep-G2 cells. Compounds 10g, 10h, 10j, 10l and 10o were found to be potent anti-HBV compounds with IC(50) values less than 50 microM. The most promising compound was 10l, with an IC(50) value of 14.7 microM and a SI value of 12.4. This is the first report of the anti-HBV effects of 6H-[1]benzothiopyrano[4,3-b] quinolin-9-ols.
Similar articles
-
Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols.Arch Pharm (Weinheim). 2009 Sep;342(9):507-12. doi: 10.1002/ardp.200900070. Arch Pharm (Weinheim). 2009. PMID: 19637181
-
Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents.Eur J Med Chem. 2011 Jan;46(1):307-19. doi: 10.1016/j.ejmech.2010.11.019. Epub 2010 Nov 19. Eur J Med Chem. 2011. PMID: 21145140
-
Synthesis and anti-hepatitis B virus activity of a novel class of thiazolylbenzimidazole derivatives.Arch Pharm (Weinheim). 2011 Feb;344(2):78-83. doi: 10.1002/ardp.201000167. Epub 2010 Dec 22. Arch Pharm (Weinheim). 2011. PMID: 21290423
-
A review of non-nucleoside anti-hepatitis B virus agents.Eur J Med Chem. 2014 Mar 21;75:267-81. doi: 10.1016/j.ejmech.2014.01.046. Epub 2014 Jan 30. Eur J Med Chem. 2014. PMID: 24549242 Review.
-
Tenofovir for the treatment of hepatitis B virus.Pharmacotherapy. 2009 Oct;29(10):1212-27. doi: 10.1592/phco.29.10.1212. Pharmacotherapy. 2009. PMID: 19792994 Review.
Cited by
-
Mannich bases in medicinal chemistry and drug design.Eur J Med Chem. 2015 Jan 7;89:743-816. doi: 10.1016/j.ejmech.2014.10.076. Epub 2014 Oct 30. Eur J Med Chem. 2015. PMID: 25462280 Free PMC article. Review.
-
Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety.Molecules. 2016 Jul 14;21(7):916. doi: 10.3390/molecules21070916. Molecules. 2016. PMID: 27428941 Free PMC article.
-
Recent advances in the chemistry of 2-chloroquinoline-3-carbaldehyde and related analogs.RSC Adv. 2018 Feb 23;8(16):8484-8515. doi: 10.1039/c7ra11537g. eCollection 2018 Feb 23. RSC Adv. 2018. PMID: 35539824 Free PMC article. Review.
-
Virtual screening of natural inhibitors to the predicted HBx protein structure of Hepatitis B Virus using molecular docking for identification of potential lead molecules for liver cancer.Bioinformation. 2014 Jul 22;10(7):428-35. doi: 10.6026/97320630010428. eCollection 2014. Bioinformation. 2014. PMID: 25187683 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
