Unlocking the molecular secrets of sodium-coupled transporters
- PMID: 19458710
- PMCID: PMC6821466
- DOI: 10.1038/nature08143
Unlocking the molecular secrets of sodium-coupled transporters
Abstract
Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.
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References
-
- Quick MW (ed.) Transmembrane Transporters (Wiley-Liss, Inc., Hoboken, NJ, 2002).
-
- Roux MJ & Supplisson S Neuronal and glial glycine transporters have different stoichiometries. Neuron 25, 373–383 (2000). - PubMed
-
- Chakrabarti AC & Deamer DW Permeability of lipid bilayers to amino acids and phosphate. Biochim. Biophys. Acta 1111, 171–177 (1992). - PubMed
-
- Supplisson S & Roux MJ Why glycine transporters have different stoichiometries. FEBS Lett. 529, 93–101 (2002). - PubMed
-
- Sobczak I & Lolkema JS Structural and mechanistic diversity of secondary transporters. Cur. Opin. Microbiol 8, 161–167 (2005). - PubMed
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