[Mechanism of protective immunity induced by irradiation-attenuated sporozoites and its implication for pre-erythrocytic malaria vaccine research]

Abstract

Irradiation-attenuated sporozoites are still the most effective pre-erythrocytic malaria vaccine However, limitation of purified sporozoites and difficulty in attenuation controlling of sporozoites hamper its use in practice. Understanding the mechanism of protective immunity induced by irradiation-attenuated sporozoites will be helpful for the design of the efficient pre-erythrocytic malaria vaccine. This is a review on research progress in the mechanism of protective immunity induced by irradiation-attenuated sporozoites and current status of pre-erythrocytic malaria vaccine development.