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. 2009 Sep;83(3):258-60.
doi: 10.1111/j.1600-0609.2009.01270.x. Epub 2009 Apr 20.

Acute splenic complications and implications of splenectomy in hemoglobin SC disease

Karthi Subbannan  1 , Celalettin Ustun, Kavita Natarajan, Betsy Clair, Lisa Daitch, Sabine Fields, Ferdane Kutlar, Abdullah Kutlar
Affiliations

Acute splenic complications and implications of splenectomy in hemoglobin SC disease

Karthi Subbannan et al. Eur J Haematol. 2009 Sep.

Abstract

Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 g/dL vs. 12.5 g/dL, P < 0.0001), platelet counts (median 146 x 10(6)/L vs. 275 x 10(6)/L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.

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