Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy

Abstract

The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.

Fig. 1

Electrointestinography (EIG) electrode position. A: Small intestine, B: Ceacum, ●: EIG mini-amplifier, ○: EIG in different electrodes.

Fig. 2

Electrointestinography maximum amplitude of the small intestine (A) and caecum (B). Preoperative value was taken as 100% and each value was shown as mean ± SD, [○: treated group (N = 6), △: control (N = 6)]. ^a,bSignificant differences (p < 0.05) compared with each preoperative value of the treated group (A) and the control group (B). ^*,^†Significant differences (p < 0.05, p < 0.01) compared between the treated group and the control group on the same day.