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Case Reports
. 2009 Jun;31(4):398-400.
doi: 10.1097/DAD.0b013e31819d845a.

Primary cutaneous blastoid mantle cell lymphoma-case report

Bruna Estrozi  1 , José A Sanches Jr, Paulo C S Varela, Carlos E Bacchi
Affiliations
Case Reports

Primary cutaneous blastoid mantle cell lymphoma-case report

Bruna Estrozi et al. Am J Dermatopathol. 2009 Jun.

Abstract

Mantle cell lymphoma (MCL) commonly involves extranodal sites, usually as a manifestation of disseminated disease. In rare cases, MCLs may arise as a primary tumor in the skin. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. The phenotype of BV-MCL is characterized as CD20+, CD5+, cyclin D1+, CD23-, and CD10-. Interphase fluorescence in situ hybridization shows a characteristic t(11;14) fusion pattern. We report a case of a BV-MCL arising in skin as primary cutaneous MCL with the characteristic immunophenotype and translocation.

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