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. 2009 Jul;59(4):335-9.
doi: 10.1007/s12576-009-0042-x. Epub 2009 May 22.

Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura

Sotirios Zarogiannis  1 , Triantafyllia Deligiorgi, Ioannis Stefanidis, Vassilios Liakopoulos, Konstantinos Gourgoulianis, Paschalis Adam Molyvdas, Chrissi Hatzoglou
Affiliations

Dexamethasone decreases the transmesothelial electrical resistance of the parietal and visceral pleura

Sotirios Zarogiannis et al. J Physiol Sci. 2009 Jul.

Abstract

The effect of dexamethasone on the transmesothelial electrical resistance (R(TM)) of sheep pleura was investigated by Ussing chamber experiments. Our results show that dexamethasone decreases the R(TM) of sheep pleurae, in part by stimulation of glucocorticoid receptors. This finding may be of importance in regard to the faster resolution of corticosteroid-treated pleural effusions.

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Figures

Fig. 1
Fig. 1
Sample experiment showing a decrease in R TM after addition of dexamethasone on the parietal pleura apically, throughout the experiment
Fig. 2
Fig. 2
Effect of dexamethasone (10−6 M; DEX), mifepristone (10−5 M; MIF) and combined effect of mifepristone (10−5 M) plus dexamethasone (10−6 M) on changes in R TM expressed as the % difference from the baseline measurement (%ΔR TM) to the apical (a) and basolateral (b) on the parietal pleura. Effect of dexamethasone (10−6 M; DEX), mifepristone (10−5 M; MIF) and combined effect of mifepristone (10−5 M) plus dexamethasone (10−6 M) on changes in R TM expressed as the % difference from the baseline measurement (%ΔR TM) to the apical (c) and basolateral (d) on the visceral pleura. Values are means ± SEM, n = 6 experiments in each case. *P < 0.05 versus control, #P < 0.05 versus dexamethasone
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