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Comparative Study
. 1991 Nov 15;88(22):10178-82.
doi: 10.1073/pnas.88.22.10178.

Cloning and expression of a widely distributed (type IV) adenylyl cyclase

B N Gao  1 , A G Gilman
Affiliations
Comparative Study

Cloning and expression of a widely distributed (type IV) adenylyl cyclase

B N Gao et al. Proc Natl Acad Sci U S A. .

Abstract

We have cloned and expressed a cDNA that encodes a widely distributed form of mammalian adenylyl cyclase (EC 4.6.1.1). Although those adenylyl cyclases described previously have a rather narrow tissue distribution, this enzyme (type IV) is apparently synthesized in a variety of peripheral tissues and in the central nervous system. The protein resembles the other adenylyl cyclases in its proposed structure. It most resembles the type II adenylyl cyclase described in the preceding paper [Feinstein, P. G., Schrader, K. A., Bakalyar, H. A., Tang, W.-J., Krupinski, J., Gilman, A. G. & Reed, R. R. (1991) Proc. Natl. Acad. Sci. USA 88, 10173-10177] in its amino acid sequence, lack of response to calmodulin, and synergistic activation by a combination of the Gs alpha subunit and the G-protein beta gamma subunit complex.

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References

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