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. 2009 Jun 2;27(27):3662-8.
doi: 10.1016/j.vaccine.2009.03.030. Epub 2009 Apr 2.

Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

Javier Capilla  1 , Karl V Clemons, Min Liu, Hillel B Levine, David A Stevens
Affiliations

Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

Javier Capilla et al. Vaccine. .

Abstract

Disseminated coccidioidomycosis is a life-threatening infection. In these studies, we examined protection against systemic murine coccidioidomycosis by vaccination with heat-killed Saccharomyces cerevisiae (HKY). CD-1 mice received HKY subcutaneously or by oral gavage with or without adjuvants once weekly beginning 3 or 4 weeks prior to infection; oral live Saccharomyces was also studied. All HKY sc regimens were equivalent, prolonging survival (P<or=0.005) and reducing fungal burden versus controls. Oral live Saccharomyces, but not HKY, prolonged survival (P=0.03), but did not reduce fungal burden. Survival of mice given HKY was equivalent to vaccination with formalin-killed spherules, but inferior in reduction of fungal burden. HKY was superior to a successful recombinant vaccine, PRA plus adjuvant. This novel heterologous protection afforded by HKY vaccination offers a new approach to a vaccine against coccidioidomycosis.

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