Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun;23(3):397-414, vii.
doi: 10.1016/j.hoc.2009.03.005.

Applications of genomics in melanoma oncogene discovery

Michael F Berger  1 , Levi A Garraway
Affiliations
Review

Applications of genomics in melanoma oncogene discovery

Michael F Berger et al. Hematol Oncol Clin North Am. 2009 Jun.

Abstract

The identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Cell signaling pathways that undergo oncogenic dysregulation in melanoma. The receptor tyrosine kinase-driven MAP kinase and PI(3)K pathways are featured.. Genes mutated in melanoma are marked with an asterisk. These include KIT, NRAS, BRAF, MITF, PI(3)K, PTEN, AKT3, and NEDD9.
See this image and copyright information in PMC

References

    1. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004 Aug;10(8):789–99. - PubMed
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57–70. - PubMed
    1. Futreal PA, Coin L, Marshall M, et al. A census of human cancer genes. Nat Rev Cancer. 2004 Mar;4(3):177–83. - PMC - PubMed
    1. Cancer Facts and Figures: 2008. American Cancer Society; Atlanta: 2008.
    1. Shih TY, Papageorge AG, Stokes PE, Weeks MO, Scolnick EM. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980 Oct 23;287(5784):686–91. - PubMed

Publication types

MeSH terms