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Case Reports
. 2009 Jul;15(7):885-6.
doi: 10.1177/1352458509104593. Epub 2009 May 22.

Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report

A H Ledinek  1 , S S Jazbec, I Drinovec, U Rot
Affiliations
Case Reports

Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report

A H Ledinek et al. Mult Scler. 2009 Jul.

Abstract

A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, associated with interferon beta therapy. As shown in experimental models, interferon treatment can induce PAH by stimulation of thromboxane cascade and secretion of various inflammatory mediators.

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