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. 2006 Feb;56(1):28-33.
doi: 10.1590/s0034-70942006000100004.

[Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them]

[Article in Portuguese]
André Kolm  1 , Alexandre Alberto Fontana Ferraz, Norma Sueli Pinheiro Módolo, Fábio Ferrari, Eliana Marisa Ganem, Geraldo Rolim Rodrigues Júnior, Paulo do Nascimento Júnior, Giane Nakamura, Lais Helena Camacho Navarro, Rodrigo Moreira Lima
Affiliations

[Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them]

[Article in Portuguese]
André Kolm et al. Rev Bras Anestesiol. 2006 Feb.

Abstract

Background and objectives: Spinal opioids may cause some undesirable effects, the most frequent of which is itching. In spite of its low morbidity rate, itching may cause severe discomfort to patients in addition to prolonging hospital stay. This study aimed at evaluating different therapeutic options to prevent itching after spinal sufentanil.

Methods: Participated in these study 100 patients scheduled for non-obstetric procedures, who were randomly distributed in five groups: control (no treatment - C); 2.5 mg droperidol (D); 10 mg nalbuphine (N); association of previous drugs (DN); and 8 mg ondansetron (O). Pruritus was quantitatively evaluated at 30 minutes, 1, 2 and 3 hours after spinal sufentanil.

Results: Groups C and O had significantly higher incidence of itching as compared to groups D, N and DN. However, there has been no significant difference in the need for specific treatment with naloxone among groups.

Conclusions: Itching prevention in our study, regardless of the drug used, has decreased its severity and has limited the need for specific treatment with naloxone.

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