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Editorial
. 2009 Jul 1;200(1):5-7.
doi: 10.1086/599379.

Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey?

Jonathan J Juliano, Steve M Taylor, Steven R Meshnick
Editorial

Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey?

Jonathan J Juliano et al. J Infect Dis. .
No abstract available

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Figures

Figure 1
Figure 1. Representative Banding Patterns for PCR Correction
These panels show typical banding patterns from pre-treatment and post-treatment samples by the WHO/MMV guidelines for PCR correction of antimalarial clinical trials. Panels A would be interpreted as a recrudescence because of a shared band before and after treatment. Panel B shows the pattern for a reinfection with no shared alleles.
See this image and copyright information in PMC

Comment on

References

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    1. World Health Organization. Methods and techniques for clinical trials on antimalarial drug efficacy: Genotyping to identify parasite populations. Geneva: World Health Organization; 2007.
    1. Juliano JJ, Kwiek JJ, Cappell K, Mwapasa V, Meshnick SR. Minority-variant pfcrt K76T mutations and chloroquine resistance, Malawi. Emerg Infect Dis. 2007;13:872–877. - PubMed

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