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. 1977 May;11(1):173-80.
doi: 10.1016/0092-8674(77)90328-2.

Developmentally regulated cyclic AMP-dependent protein kinases in Dictyostelium discoideum

Developmentally regulated cyclic AMP-dependent protein kinases in Dictyostelium discoideum

J Sampson. Cell. 1977 May.

Abstract

Two apparently distinct species of cyclic AMP-dependent protein kinase appear during the first 1-2 hr of development in Dictyostelium discoideum; no such activity can be detected in vegetative cell extracts. These two kinases are similar in properties to the type I and II cyclic AMP-dependent protein kinases found in a number of mammalian tissues. Their time of appearance supports the idea that one or both mediate the effects of cyclic AMP on gene expression early in Dictyostelium development.

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