Developmentally regulated cyclic AMP-dependent protein kinases in Dictyostelium discoideum
- PMID: 194703
- DOI: 10.1016/0092-8674(77)90328-2
Developmentally regulated cyclic AMP-dependent protein kinases in Dictyostelium discoideum
Abstract
Two apparently distinct species of cyclic AMP-dependent protein kinase appear during the first 1-2 hr of development in Dictyostelium discoideum; no such activity can be detected in vegetative cell extracts. These two kinases are similar in properties to the type I and II cyclic AMP-dependent protein kinases found in a number of mammalian tissues. Their time of appearance supports the idea that one or both mediate the effects of cyclic AMP on gene expression early in Dictyostelium development.
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