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Review
. 2009 Jun;2(6):514-7.
doi: 10.1158/1940-6207.CAPR-09-0083. Epub 2009 May 26.

Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail

Ann M Bode  1 , Zigang Dong
Affiliations
Review

Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail

Ann M Bode et al. Cancer Prev Res (Phila). 2009 Jun.
No abstract available

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Figures

Fig. 1
Fig. 1
EGCG interacts with and binds numerous proteins to prevent carcinogenesis. EGCG has been reported to directly bind with the plasma proteins fibronectin, fibrinogen and histidine-rich glycoprotein, Fas, laminin and the 67 kDa laminin receptor, vimentin ZAP-70, Fyn, insulin-line growth factor-I receptor (IGF-IR), and glucose-regulated protein 78 (GRP-78; solid arrows). EGCG also indirectly targets a number of other oncogenic proteins including EGFR and the activator protein 1 (AP-1), signal transducers and activators of transcription (STAT), and nuclear factor κB (NF-κB) transcription factors. The net result is the inhibition of carcinogenesis in a variety of tissues.
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Comment on

References

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