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. 2008 Dec;19(4):218-22.
doi: 10.3802/jgo.2008.19.4.218. Epub 2008 Dec 29.

Gynecologic oncology group trials in uterine corpus malignancies: recent progress

David Scott Miller  1 , Louise P King
Affiliations

Gynecologic oncology group trials in uterine corpus malignancies: recent progress

David Scott Miller et al. J Gynecol Oncol. 2008 Dec.

Abstract

The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances.

Keywords: Carcinosarcoma; Clinical trial; Endometrial neoplasm.

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Figures

Fig. 1
Fig. 1
A phase III randomized clinical trial of laparoscopic pelvic and para-aortic node sampling with vaginal hysterectomy and BSO versus open laparotomy with pelvic and para-aortic node sampling and abdominal hysterectomy and BSO in endometrial adenocarcinoma and uterine sarcoma, clinical stage I, IIA, Grade I, II, III.
Fig. 2
Fig. 2
Whole abdominal radiotherapy versus combination doxorubicin-cisplatin chemotherapy in advanced endometrial carcinoma (phase III).
Fig. 3
Fig. 3
A randomized phase III study of tumor volume directed pelvic plus or minus para-aortic irradiation followed by cisplatin and doxorubicin or cisplatin, doxorubicin and paclitaxel for advanced endometrial carcinoma.
Fig. 4
Fig. 4
A phase III randomized study of whole abdominal radiotherapy versus combination ifosfamide-mesna with cisplatin in optimally debulked stage I, II, III or IV carcinosarcoma of the uterus.
Fig. 5
Fig. 5
A phase III trial of ifosfamide versus ifosfamide plus paclitaxel in patients with advanced, persistent, or recurrent carcinosarcoma (mixed mesodermal tumors) of the uterus.
See this image and copyright information in PMC

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