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. 2003 Sep;53(5):586-90.

Analgesia and sedation with epidural clonidine associated to 0.75% ropivacaine in the postoperative period of open cholecystectomy

[Article in English, Portuguese]
Antonio Mauro Vieira  1 , Taylor Brandão Schnaider, Flávio Aparecido Costa, Everaldo Donizeti Costa
Affiliations
  • PMID: 19475312

Analgesia and sedation with epidural clonidine associated to 0.75% ropivacaine in the postoperative period of open cholecystectomy

[Article in English, Portuguese]
Antonio Mauro Vieira et al. Rev Bras Anestesiol. 2003 Sep.

Abstract

Background and objectives: Epidural clonidine has analgesic properties and potentiates local anesthetic effects; there are, however, some side effects including: arterial hypotension, bradycardia and sedation. This study aimed at evaluating analgesia and sedation of clonidine associated to 0.75% ropivacaine in the postoperative period of open cholecystectomy.

Methods: Participated in this study 30 patients of both genders, aged 18 to 50 years, weighing 50 to 100 kg, physical status ASA I or II, submitted to cholecystectomy, who were distributed in two groups: Control Group (CG) received 0.75% ropivacaine (20 ml) with saline solution (1 ml); Experimental Group (EG) received 0.75% ropivacaine (20 ml) with clonidine (1 ml = 150 microg). Analgesia and sedation were observed at 2, 6 and 24 postoperative hours.

Results: Mean age was 41 yr in CG and 37 yr in EG. Mean weight was 67 kg in CG and 64 kg to EG. Postoperative sedation was significantly higher at 2 and 6 hours in the Experimental Group. Analgesia was observed in more EG patients as compared to Control Group.

Conclusions: The association of clonidine and ropivacaine has produced longer analgesia and sedation at 2 and 6 hours of observation.

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