Obesity and thyrotropinemia

Abstract

Objective: To study the relation between body mass index (BMI) and TSH in euthyroid and subclinical hypothyroid obese children and compared serum TSH level among obese and overweight children.

Methods: Fifty consecutive children (aged 2-18 yr) presenting for obesity were studied. All cases with TSH > 10, low T3/T4, organic and syndromic obesity were excluded. Patients were divided into Group 1: Overweight (n=20) (BMI between 85(th) to 95(th) centile) and Group 2: Obesity (n=30) (BMI > 95(th) centile). Fisher's exact test, Mann-Whitney U test and Pearson's correlation were used for statistical analysis. P value < 0.05 was considered significant.

Results: Elevated TSH level (between 4.5-10 mIU/L) with normal T3, T4 was seen in 4/20 overweight and 9/30 of obese children (P=0.5219). The mean TSH was comparable in both the groups (3.22 +/- 3.1 mIU/L vs. 3.63 +/- 2.2 mIU/L, P=0.3491). Overall TSH showed no correlation with BMI (r= 0.0014, P=0.9924).

Conclusion: The preliminary data did not show any relation between severity of obesity and TSH level. Further large scale data from population are required to confirm these findings.