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Review
. 2009 Jul;109(7):2880-93.
doi: 10.1021/cr900028p.

Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer

William B Parker  1
Affiliations
Review

Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer

William B Parker. Chem Rev. 2009 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Primary enzymes involved in the metabolism of pyrimidine analogues.
Figure 2
Figure 2
Primary enzymes involved in the metabolism of purine analogues.
Figure 3
Figure 3
Structures of thiopurines.
Figure 4
Figure 4
Metabolism of mercaptopurine and thioguanine.
Figure 5
Figure 5
Structures of fluoropyrimidines.
Figure 6
Figure 6
Metabolism of fluoropyrimidines.
Figure 7
Figure 7
Structures of deoxycytidine analogues.
Figure 8
Figure 8
Deoxycytidine metabolism.
Figure 9
Figure 9
Structures of deoxyadenosine analogues.
Figure 10
Figure 10
Structure of nelarabine.
Figure 11
Figure 11
Deoxyadenosine and deoxyguanosine metabolism.
Figure 12
Figure 12
Structures of troxacitabine, thio-araC, CNDAC, and forodesine.
Figure 13
Figure 13
Gene therapy approaches to the treatment of cancer.
See this image and copyright information in PMC

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