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. 2009 Aug;36(4):207-11.
doi: 10.1111/j.1744-313X.2009.00849.x. Epub 2009 May 19.

Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded

M J Chen  1 , T C Yang, C C Chu, M H Shyr, C L Lin, P Y Lin, K L Yang
Affiliations

Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded

M J Chen et al. Int J Immunogenet. 2009 Aug.

Abstract

We report here a novel HLA-B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T-->A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA-Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4-specific allele (probably B*2704) and a Bw6-specific allele.

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