Transcriptional regulation and alternative splicing make for better brains
- PMID: 19477147
- DOI: 10.1016/j.neuron.2009.05.006
Transcriptional regulation and alternative splicing make for better brains
Abstract
In this issue of Neuron, Johnson et al. employ a unique whole-genome exon-level analysis of the developing human brain showing that 76% of genes are expressed along with unexpectedly high levels of differential expression. These results have important consequences for understanding normal and pathological function and provide implications about the uniqueness of being human.
Comment on
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Functional and evolutionary insights into human brain development through global transcriptome analysis.Neuron. 2009 May 28;62(4):494-509. doi: 10.1016/j.neuron.2009.03.027. Neuron. 2009. PMID: 19477152 Free PMC article.
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