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. 2009 Aug 28;460(2):130-2.
doi: 10.1016/j.neulet.2009.05.057. Epub 2009 May 27.

Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

Elizabeth Regina Comini Frota  1 , David Henrique Rodrigues, Eduardo Antonio Donadi, Doralina G Brum, Damacio Ramon Kaimen Maciel, Antônio Lúcio Teixeira
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Free article

Increased plasma levels of brain derived neurotrophic factor (BDNF) after multiple sclerosis relapse

Elizabeth Regina Comini Frota et al. Neurosci Lett. .
Free article

Abstract

Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role in multiple sclerosis (MS) was only partially investigated. In this work, we aimed to evaluate the plasma levels of BDNF from 29 MS patients and 24 control subjects. MS patients had decreased levels of BDNF in comparison with healthy controls. BDNF levels increased significantly after MS relapse. Our results provide some evidence for the involvement of BDNF in the pathogenesis of MS and suggest a role for this neurotrophin during the recovery of acute demyelinating inflammatory lesion.

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