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Comparative Study
. 1991 Oct 25;254(5031):578-9.
doi: 10.1126/science.1948035.

Cloning and expression of a cocaine-sensitive rat dopamine transporter

J E Kilty  1 , D Lorang, S G Amara
Affiliations
Comparative Study

Cloning and expression of a cocaine-sensitive rat dopamine transporter

J E Kilty et al. Science. .

Abstract

The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.

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