Comparative Study
doi: 10.1126/science.1948035.
Cloning and expression of a cocaine-sensitive rat dopamine transporter
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- PMID: 1948035
- DOI: 10.1126/science.1948035
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Comparative Study
Cloning and expression of a cocaine-sensitive rat dopamine transporter
Science.
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Abstract
The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.
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