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Review
. 2009 Oct;41(10):1972-6.
doi: 10.1016/j.biocel.2009.05.013. Epub 2009 May 27.

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex

Xingguo Liu  1 , György Hajnóczky
Affiliations
Review

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex

Xingguo Liu et al. Int J Biochem Cell Biol. 2009 Oct.

Abstract

Calcium oscillations control mitochondrial motility along the microtubules and in turn, support on-demand distribution of mitochondria. However, the mechanism mediating the Ca(2+) effect remained a mystery. Recently, several papers reported on the Ca(2+)-dependent regulation of mitochondrial dynamics by a Miro-Milton complex linking mitochondria to kinesin motors. Both mitochondrial motility and fusion-fission dynamics seem to be sensitive to a Ca(2+)-dependent switch by this complex. Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca(2+)-induced cell injury.

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Figures

Figure 1
Figure 1
Ca2+-dependent control of both mitochondrial motility and fusion-fission dynamics by the Miro-Milton complex
See this image and copyright information in PMC

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