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Editorial
. 2009 Jul;137(1):33-6.
doi: 10.1053/j.gastro.2009.05.011. Epub 2009 May 29.

Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis

John M Carethers
Editorial

Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis

John M Carethers. Gastroenterology. 2009 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Schematic diagram of the Wnt and TGF-β signaling pathways, and their common transcriptional target and mediator, BAMBI.
See this image and copyright information in PMC

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References

    1. Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology. 2008;135:1079–1099. - PMC - PubMed
    1. Lin Z, Gao C, Ning Y, et al. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem. 2008;283:33053–33058. - PMC - PubMed
    1. Sekiya T, Adachi S, Kohu K, et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem. 2004;279:6840–6846. - PubMed
    1. Beck SE, Jung BH, Fiorino A, et al. Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol. 2006;291:G135–G145. - PMC - PubMed
    1. Jung B, Doctolero RT, Tajima A, et al. Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. Gastroenterology. 2004;126:654–659. - PubMed

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