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. 2009 Nov;15(9):703-5.
doi: 10.1016/j.parkreldis.2009.05.001. Epub 2009 May 31.

GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

Alessio Di Fonzo  1 , Edito Fabrizio, Astrid Thomas, Emiliana Fincati, Roberto Marconi, Michele Tinazzi, Guido J Breedveld, Erik J Simons, Hsin F Chien, Joaquim J Ferreira, Martin W Horstink, Giovanni Abbruzzese, Barbara Borroni, Giovanni Cossu, Alessio Dalla Libera, Giovanni Fabbrini, Marco Guidi, Michele De Mari, Leonardo Lopiano, Emilia Martignoni, Paolo Marini, Marco Onofrj, Alessandro Padovani, Fabrizio Stocchi, Vincenzo Toni, Cristina Sampaio, Egberto R Barbosa, Giuseppe Meco; Italian Parkinson Genetics Network; Ben A Oostra, Vincenzo Bonifati
Collaborators, Affiliations

GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

Alessio Di Fonzo et al. Parkinsonism Relat Disord. 2009 Nov.

Abstract

Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD.

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