How diverse--CD4 effector T cells and their functions

Abstract

CD4 effector T cells, also called helper T (Th) cells, are the functional cells for executing immune functions. Balanced immune responses can only be achieved by proper regulation of the differentiation and function of Th cells. Dysregulated Th cell function often leads to inefficient clearance of pathogens and causes inflammatory diseases and autoimmunity. Since the establishment of the Th1-Th2 dogma in the 1980s, different lineages of effector T cells have been identified that not only promote but also suppress immune responses. Through years of collective efforts, much information was gained on the function and regulation of different subsets of Th cells. In this review, we attempt to sample the essence of what has been learnt in this field over the past two decades. We will discuss the classification and immunological functions of effector T cells, the determinants for effector T cell differentiation, as well as the relationship between different lineages of effector T cells.

Figure 1

The balancing act of cytokines in Th differentiation and conversion. Largely through the effects of cytokines, different types of Th cells counterbalance each other to achieve immune homeostasis. Under certain circumstances, one type of Th cell converts into another (shown by dotted green lines) to facilitate desired immune responses.