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Clinical Trial
. 2009 Jul;28(7):655-8.
doi: 10.1097/INF.0b013e318199c3b1.

Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children

Margarita Gomez  1 , Maurice A Mufson, Filip Dubovsky, Conor Knightly, Wen Zeng, Genevieve Losonsky
Affiliations
Clinical Trial

Phase-I study MEDI-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children

Margarita Gomez et al. Pediatr Infect Dis J. 2009 Jul.

Abstract

A live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine was evaluated in healthy respiratory syncytial virus/parainfluenza virus type 3 seropositive children aged 1 to 9 years. Three cohorts of 40 children were randomized 1:1 to receive 10, 10, or 10 median tissue culture infectious dose50 MEDI-534 vaccine or placebo. The vaccine's safety profile was similar to placebo, no viral shedding was detected, and the vaccine was minimally immunogenic.

Trial registration: ClinicalTrials.gov NCT00345670.

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