Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Aug;53(8):3544-8.
doi: 10.1128/AAC.00400-09. Epub 2009 Jun 1.

AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

James A Karlowsky  1 , Nachum Kaplan, Barry Hafkin, Daryl J Hoban, George G Zhanel
Affiliations

AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

James A Karlowsky et al. Antimicrob Agents Chemother. 2009 Aug.

Abstract

AFN-1252, a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus (n = 502) and Staphylococcus epidermidis (n = 51) tested, including methicillin (meticillin)-resistant isolates, at concentrations of <or=0.12 microg/ml. In contrast, AFN-1252 was inactive (MIC(90), >4 microg/ml) against clinical isolates of Streptococcus pneumoniae, beta-hemolytic streptococci, Enterococcus spp., Enterobacteriaceae, nonfermentative gram-negative bacilli, and Moraxella catarrhalis. These data support the continued development of AFN-1252 for the treatment of patients with resistant staphylococcal infections.

PubMed Disclaimer

References

    1. Campbell, J. W., and J. E. Cronan, Jr. 2001. Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu. Rev. Microbiol. 55:305-332. - PubMed
    1. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement, M100-S17, vol. 27, no. 1. Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; M7-A7, approved standard, 7th ed. Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Reference deleted.
    1. Reference deleted.

Publication types

MeSH terms