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Multicenter Study
. 2009 Aug;32(8):1550-2.
doi: 10.2337/dc09-0256. Epub 2009 Jun 1.

Poor glycemic control is an independent risk factor for low HDL cholesterol in patients with type 2 diabetes

Alessandra Gatti  1 , Marianna Maranghi, Simonetta Bacci, Claudio Carallo, Agostino Gnasso, Elisabetta Mandosi, Mara Fallarino, Susanna Morano, Vincenzo Trischitta, Sebastiano Filetti
Affiliations
Multicenter Study

Poor glycemic control is an independent risk factor for low HDL cholesterol in patients with type 2 diabetes

Alessandra Gatti et al. Diabetes Care. 2009 Aug.

Abstract

OBJECTIVE To determine whether the association observed between poor glycemic control and low HDL cholesterol in type 2 diabetes is dependent on obesity and/or hypertriglyceridemia. RESEARCH DESIGN AND METHODS We performed a cross-sectional study of 1,819 patients with type 2 diabetes and triglycerides <400 mg/dl enrolled at three diabetes centers in Italy. The risk for low HDL cholesterol was analyzed as a function of A1C levels. Odds ratios (ORs) were calculated after adjustment for confounding factors. RESULTS A 1% increase in A1C significantly increased the risk for low HDL cholesterol (OR 1.17 [95% CI 1.1-1.2], P = 0.00072); no changes were observed when age, sex, smoking, and lipid-lowering therapy were included in the model (1.17 [1.1-1.2], P = 0.00044). The association remained strong after adjustments for obesity and hypertriglyceridemia in multivariate analysis (1.12 [1.05-1.18], P = 0.00017). CONCLUSIONS Poor glycemic control appears to be an independent risk factor for low HDL cholesterol in type 2 diabetes.

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