Review
doi: 10.1002/0471142700.nc0104s37.
Unnatural nucleosides with unusual base pairing properties
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- PMID: 19488968
- DOI: 10.1002/0471142700.nc0104s37
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Review
Unnatural nucleosides with unusual base pairing properties
Curr Protoc Nucleic Acid Chem.
2009 Jun.
Abstract
Synthetic modified nucleosides designed to pair in unusual ways with natural nucleobases have many potential applications in biology and biotechnology. This overview lays the foundation for future protocol units on synthesis and application of unnatural bases, with particular emphasis on unnatural base analogs that mimic natural bases in size, shape, and biochemical processing. Topics covered include base pairs with alternative H-bonding schemes, dimensionally expanded base pairs, hydrophobic base pairs, metal-ligated bases, degenerate bases, universal nucleosides, and triplex constituents.
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