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. 2009 Jun;9(6):485-7.
doi: 10.1016/j.cmet.2009.05.007.

Metformin and insulin meet in a most atypical way

Morris F White  1
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Free article

Metformin and insulin meet in a most atypical way

Morris F White. Cell Metab. 2009 Jun.
Free article

Abstract

A recent Cell paper by He et al. (2009) shows how metformin circumvents a block between insulin and atypical protein kinase C in obese and diabetic mice to inhibit gluconeogenesis by stimulating the phosphorylation of CBP and the disassembly of the CREB transcriptional complex.

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