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Review
. 2009 Jul;8(3):147-9.
doi: 10.1016/j.arr.2009.03.002. Epub 2009 Mar 21.

Clathrin-mediated endocytosis and Alzheimer's disease: an update

Fangbai Wu  1 , Pamela J Yao
Affiliations
Review

Clathrin-mediated endocytosis and Alzheimer's disease: an update

Fangbai Wu et al. Ageing Res Rev. 2009 Jul.

Abstract

Thanks to new evidence we are now a step closer to understanding how neurons produce amyloid-beta peptide (Abeta)-the chief culprit of Alzheimer's disease. As importance of clathrin-mediated endocytosis to normal neurons has become clearer, so has its role in pathology of neurological disorders. Here we update recent evidence that endocytosis plays a central role in the production of Abeta in neurons.

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