Review
doi: 10.1016/0968-0004(91)90137-k.
Helix-loop-helix genes translocated in lymphoid leukemia
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- PMID: 1949153
- DOI: 10.1016/0968-0004(91)90137-k
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Review
Helix-loop-helix genes translocated in lymphoid leukemia
Trends Biochem Sci.
1991 Sep.
Abstract
A new class of DNA-binding proteins with a helix-loop-helix (HLH) structure has recently been described. Many of these transcriptional regulators are known to play a central role in cell-specification and differentiation processes. Four members of the HLH family are now implicated in the development of human lymphoid malignancies as a result of aberrant expression following chromosomal translocation events. This review focuses on two of these family members: SCL and LYL-1.
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