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Review
. 1991 Sep;16(9):330-3.
doi: 10.1016/0968-0004(91)90137-k.

Helix-loop-helix genes translocated in lymphoid leukemia

J Visvader  1 , C G Begley
Affiliations
Review

Helix-loop-helix genes translocated in lymphoid leukemia

J Visvader et al. Trends Biochem Sci. 1991 Sep.

Abstract

A new class of DNA-binding proteins with a helix-loop-helix (HLH) structure has recently been described. Many of these transcriptional regulators are known to play a central role in cell-specification and differentiation processes. Four members of the HLH family are now implicated in the development of human lymphoid malignancies as a result of aberrant expression following chromosomal translocation events. This review focuses on two of these family members: SCL and LYL-1.

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