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Review
. 1991 Sep;16(9):338-41.
doi: 10.1016/0968-0004(91)90139-m.

The G protein connection: molecular basis of membrane association

A M Spiegel  1 , P S Backlund Jr, J E Butrynski, T L Jones, W F Simonds
Affiliations
Review

The G protein connection: molecular basis of membrane association

A M Spiegel et al. Trends Biochem Sci. 1991 Sep.

Erratum in

  • Trends Biochem Sci 1992 May;17(5):177

Abstract

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

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