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. 2009 Jul 15;20(11):1037-41.
doi: 10.1097/WNR.0b013e32832e0ca7.

Absence of M100 source asymmetry in autism associated with language functioning

Gwenda L Schmidt  1 , Michael M Rey, Janis E Oram Cardy, Timothy P L Roberts
Affiliations

Absence of M100 source asymmetry in autism associated with language functioning

Gwenda L Schmidt et al. Neuroreport. .

Abstract

Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with language functioning. Evoked neural activity to a 1 kHz tone was recorded using whole-cortex 151-channel magnetoencephalography in three groups of individuals. A single-dipole model identified the M100 generator in auditory cortex in each hemisphere. Healthy adults and control children displayed the expected right-sided M100 anteriority, whereas children with autism showed no such asymmetry. An association was found between language functioning and the degree of asymmetry across the two groups of children, suggesting a possible relationship between functional-structural asymmetry and language ability.

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Figures

Fig. 1
Fig. 1
Asymmetry data for the three participant groups. Adult and child controls show a clear rightward anteriority, whereas children with autism show no clear overall pattern.
Fig. 2
Fig. 2
Correlation of asymmetry index and the Clinical Evaluation of Language Fundamentals — 4th edition (CELF-4 score). The line depicts the correlation for the combined group of children. X left, left hemisphere x-axis; X right, right hemisphere x-axis.
See this image and copyright information in PMC

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