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Comment
. 2009 Jun 3;28(11):1533-4.
doi: 10.1038/emboj.2009.130.

Fussy mitochondria fuse in response to stress

Alexander M van der Bliek  1
Affiliations
Comment

Fussy mitochondria fuse in response to stress

Alexander M van der Bliek. EMBO J. .
No abstract available

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Figures

Figure 1
Figure 1
Mitochondrial fission and fusion cycles normally consist of fission mediated by DRP1 and fusion mediated by MFN1, MFN2 and the short and long forms (S and L) of OPA1. Cells that are committed to apoptosis (equated here with high levels of stress) use DRP1-mediated fission to promote cytochrome c release. The newly discovered SIMH pathway, which is induced by low levels of stress, has the opposite effect, namely the formation of a closed mitochondria network through the actions of MFN1 and L-OPA1, but not MFN2 or S-OPA1, SIMH pathway confers resistance to further stress, but eventually cells might succumb to apoptosis.
See this image and copyright information in PMC

Comment on

  • SLP-2 is required for stress-induced mitochondrial hyperfusion.
    Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC. Tondera D, et al. EMBO J. 2009 Jun 3;28(11):1589-600. doi: 10.1038/emboj.2009.89. Epub 2009 Apr 9. EMBO J. 2009. PMID: 19360003 Free PMC article.

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