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Review
. 2009 Jun 5;4(6):503-6.
doi: 10.1016/j.stem.2009.05.011.

Bone and blood vessels: the hard and the soft of hematopoietic stem cell niches

Russell W Garrett  1 , Stephen G Emerson
Affiliations
Free article
Review

Bone and blood vessels: the hard and the soft of hematopoietic stem cell niches

Russell W Garrett et al. Cell Stem Cell. .
Free article

Abstract

Osteoblasts are important regulators of myelopoiesis and lymphopoiesis, producing several necessary soluble and membrane-associated factors. In addition, they may play important roles, along with other mesenchymal populations, in constructing an environment that is suitable for development of sinusoidal niches capable of supporting hematopoietic stem cells.

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