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Review
. 2009 Jun;21(3):298-304.
doi: 10.1016/j.coi.2009.05.019. Epub 2009 Jun 6.

Human B cell memory

Antonio Lanzavecchia  1 , Federica Sallusto
Affiliations
Review

Human B cell memory

Antonio Lanzavecchia et al. Curr Opin Immunol. 2009 Jun.

Abstract

Following an immune response two types of differentiated B cells persist in the memory pool: plasma cells, which confer immediate protection by the secretion of specific antibodies; and memory B cells, which confer rapid and enhanced response to secondary challenge. We will review recent advances in understanding the heterogeneity, dynamics, and persistence of human memory B cells and plasma cells as well as new methods to isolate human monoclonal antibodies. These findings offer new insights into the human B cell response, which are relevant for vaccination and therapeutic intervention.

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References

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    2. An excellent review that discusses current concepts on the dynamics of long-lived plasma cells in the bone marrow.

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