Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Jun;15(6):612-3.
doi: 10.1038/nm0609-612.

IFN-alpha wakes up sleeping hematopoietic stem cells

Emmanuelle Passegué, Patricia Ernst
Comment

IFN-alpha wakes up sleeping hematopoietic stem cells

Emmanuelle Passegué et al. Nat Med. 2009 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Role of low-level and induced IFNα signaling within HSCs
A) Hypothetical target gene linking IFNα signaling to HSC proliferation. The upper panel illustrates IFNα-induced proliferation via the ISGF3 complex and the lower panel depicts endogenous level (uninduced) IFNα signaling in which IRF2 acts on the same hypothetical gene to constitutively supress expression. B) Outcome of HSC proliferation in the presence of endogenous IFNα signaling, induced IFNα signaling (↑IFNα) and in the IRF2 knockout. Arrows indicate decisions of the stem cell to divide to yield mostly progeny commmitting to differentiate (green cells) versus dividing to self-renew and maintain the stem cell pool (purple cells).
See this image and copyright information in PMC

Comment on

References

    1. Wilson A, et al. Dormant and self-renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci. 2007;1106:64–75. - PubMed
    1. Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle. 2008;7:586–91. - PMC - PubMed
    1. Essers MA, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 2009;458:904–8. - PubMed
    1. Sato T, et al. IRF-2 protects quiescent HSCs from type-I interferon-dependent exhaustion. Nature Medicine. 2009 this issue. - PubMed
    1. Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005;5:375–86. - PubMed

MeSH terms

Substances